Adjunctive Study Between Fine Needle Aspiration Cytology and Histopathological Results of Thyroid Nodules

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Published Dec 22, 2023
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Vol. 1 No. 03 (2023): MISJ-International Journal of Medical Research and Allied Sciences

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Faraj A. Aljali1, Azeza Gum S. S.2, Fathi A. Abdalla Asnini1, Ahmed G.Y. Elsayed3, Laila M. Elgendy 3, Ahmed F.A. Asnini4, Guda A.G. Yousef4, Mohamed R. Milad4, Mohammed A. Bohoush4, Moaaz S.K. Abdelnabi4
1General surgery department, Fculty of medicine, Tobruk University, Tobruk, Libya 2Omar Al-Mukhtar University, Faculty of Medical Technology,Department of Lab. Medicine, Box 919, Al-Bayda, Libya 3Pathology department, Tobruk Medical Center, Tobruk, Libya 3Biochemistry department, Tobruk Medical Center, Tobruk, Libya. 4 Medical Students, Fculty of medicine, Tobruk University, Tobruk, Libya

Abstract

Introduction: Fine needle aspiration cytology (FNAC) is an effective method for the differential diagnosis of thyroid nodules. The Bethesda system helped define the clinical approach by standardizing cytopathology reports. However, the percentage of cytological-histological incompatibility varies between 10% and 30%. Results in the literature vary by clinic. These results warrant reassessment of the efficacy and safety of fine-needle aspiration biopsy.


Aim of the work: Evaluate the diagnostic accuracy of FNAC for thyroid nodules by correlating the cytopathological results of FNAC with postoperative histopathological results.


Materials and Methods: In this retrospective study, thyroid FNAC results and postoperative histopathological examination results were compared in patients who underwent thyroidectomy at our hospital from January 2016 to December 2021.Accuracy, sensitivity (Sn), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), false positive rate (FPR) and false negative rate (FNR) were calculated. Cases with non-diagnostic FNAC results were excluded from the calculations. FNAC results with follicular neoplasm/suspected follicular neoplasm (FN/SFN) and suspected malignancy were included in the malignancy group.


Results: A total of 91 patients were included in the study. The male/female ratio was 1:21.75. As a result of the study, malignancy was detected histopathologically in 9 (9.9%) patients. The commonest malignancy detected was papillary carcinoma. According to the Bethesda system, the results were evaluated in six categories but no cases in I and VI. The incidence of malignancy in the Bethesda categories were 2.9%, 7.7%, 40% and 100%, respectively. Accordingly, the specificity and sensitivity of FNAC for detecting malignancy were 96.3% and 66.6%, respectively. The accuracy was 93.4%. The false positive rate, false negative rate, positive predictive value, and negative predictive value were 3.7%, 33.3%, 66.6%, and 96.3%, respectively.


Conclusion: In conclusion, FNAC is a valid method for the differential diagnosis of thyroid nodules and provides a satisfactory level of reliability.


 


Keywords: Fine Needle Aspiration Cytology; Histopathology; Thyroid Nodule.


 

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How to Cite
Faraj A. Aljali1, Azeza Gum S. S.2, Fathi A. Abdalla Asnini1, Ahmed G.Y. Elsayed3, Laila M. Elgendy 3, Ahmed F.A. Asnini4, Guda A.G. Yousef4, Mohamed R. Milad4, Mohammed A. Bohoush4, Moaaz S.K. Abdelnabi4. (2023). Adjunctive Study Between Fine Needle Aspiration Cytology and Histopathological Results of Thyroid Nodules. MISJ-International Journal of Medical Research and Allied Sciences, 1(03), Page: 156–161. Retrieved from https://ijmraas.misj.net/index.php/ijmraas/article/view/17