Seroprevalence of Antibodies Against To RCH Infectious Pathogens (Toxoplasma gondii, Rubella and Cytomegalovirus) Among Pregnant Women in El-Beida City

Abstract

An infections of pregnant women by Toxoplasma gondii, Rubella and Cytomegalovirus (CMV) can lead to intrauterine infection that leads to congenital anomalies in the fetus during pregnancy. These complications range from early pregnancy miscarriage to fetal abnormalities such as physical deformities, poor vision, and delayed neurological, hearing, and mobility. This study was conducted to examine the seroprevalence of antibodies to T. gondii, CMV, and Rubella in Al-Beida city. 71 pregnant women was tested using an enzyme linked immunosorbent assay method ELISA to reveal of presence of antibodies (IgG and IgM) T. gondii, Rubella virus and cytomegalovirus (CMV) in blood serum. Data from serum samples showed that CMV seroprevalence was the highest followed by rubella, then T. gondii that was found to be CMV seropositive (IgG/IgM) 94%, Rubella (IgG/ IgM) 90% and T. gondii (IgG/ IgM) 60%. the highest level of IgG in all age groups was found in CMV 90% with a mean (2.845), then in Rubella virus 87% with a mean (1.896) and the low level reported in T. gondii IgG 57.7% with a mean (0.831). These results may give a better understanding of which rubella, toxoplasma and cytomegalovirus infections was more common and more effected on pregnancy leading to fetal loss.

Keywords: T. gondi, Cytomegalovirus and Rubella virus.